A molecular insight into the lipid changes of pig Longissimus thoracis muscle following dietary supplementation with functional ingredients

Gabriele Rocchetti, Marika Vitali, Martina Zappaterra, Laura Righetti, Rubina Sirri, Luigi Lucini, Chiara Dall’Asta, Roberta Davoli and Gianni Galaverna

PLOS ONE, 2022, vol. 17, issue 3, 1-24

Abstract: In this work, the Longissimus thoracis pig skeletal muscle was used as a model to investigate the impact of two different diets, supplemented with n-3 polyunsaturated fatty acids from extruded linseed (L) and polyphenols from grape skin and oregano extracts (L+P), on the lipidomic profile of meat. A standard diet for growing-finishing pigs (CTRL) was used as a control. Changes in lipids profile were investigated through an untargeted lipidomics and transcriptomics combined investigation. The lipidomics identified 1507 compounds, with 195 compounds fitting with the MS/MS spectra of LipidBlast database. When compared with the CTRL group, the L+P diet significantly increased 15 glycerophospholipids and 8 sphingolipids, while the L diet determined a marked up-accumulation of glycerolipids. According to the correlations outlined between discriminant lipids and genes, the L diet may act preventing adipogenesis and the related inflammation processes, while the L+P diet promoted the expression of genes involved in lipids’ biosynthesis and adipogenic extracellular matrix formation and functioning.

Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0264953

DOI: 10.1371/journal.pone.0264953

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