Spectral homogeneity of human platelets investigated by SERS

Andrey Zyubin, Vladimir Rafalskiy, Mikhail Lopatin, Elizaveta Demishkevich, Ekaterina Moiseeva, Karina Matveeva, Igor Kon, Artemii Khankaev, Anna Kundalevich, Viktoria Butova, Leonard Lipnevich, Ivan Lyatun, Ilia Samusev and Valery Bryukhanov

PLOS ONE, 2022, vol. 17, issue 5, 1-14

Abstract: This paper describes a detailed study of the spectral homogeneity of human platelets using Surface-enhanced Raman spectroscopy (SERS). We used a combined approach based on multivariate methods as principal component analysis and pair correlation algorithms to investigate platelets spectral properties. The correlation coefficients for each sample have been calculated, and the average coefficient of determination has been estimated. The high degree of spectral homogeneity inside one probe and between them has been revealed. The prospects of obtained results usage for pathologies based on platelet conformations during cardiovascular diseases have been demonstrated.

Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0265247

DOI: 10.1371/journal.pone.0265247

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