Diagnostic efficacy of the magnetic resonance T1w/T2w ratio for the middle cerebellar peduncle in multiple system atrophy and spinocerebellar ataxia: A preliminary study

Jiaqi Wang, Atsuhiko Sugiyama, Hajime Yokota, Shigeki Hirano, Graham Cooper, Hiroki Mukai, Kenji Ohira, Kyosuke Koide, Shoichi Ito, Carsten Finke, Alexander U Brandt, Friedemann Paul and Satoshi Kuwabara

PLOS ONE, 2022, vol. 17, issue 4, 1-15

Abstract: Background: The standardized T1-weighted/T2-weighted (sT1w/T2w) ratio for the middle cerebellar peduncle (MCP) has been reported to be sensitive for detecting degenerative changes in the cerebellar subtype of multiple system atrophy (MSA-C), even in the early stages. We aimed to investigate the diagnostic value of the MCP sT1w/T2w ratio for differentiating between MSA-C and spinocerebellar ataxia (SCA). Methods: We included 32 MSA-C, 8 SCA type 3 (SCA3), 16 SCA type 6 (SCA6) patients, and 17 controls, and the MCP sT1w/T2w ratio was analyzed using a region-of-interest approach. The diagnostic performance of the MCP sT1w/T2w ratio in discriminating among MSA-C, SCA3, and SCA6 was assessed and compared with diagnosis based on visual interpretation of MCP hyperintensities and the “hot cross bun” (HCB) sign. Results: MCP sT1w/T2w ratio values were markedly lower in patients with MSA-C than in those with SCA3, those with SCA6, and controls (p

Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0267024

DOI: 10.1371/journal.pone.0267024

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