The clinical value of miRNA-21 in cervical cancer: A comprehensive investigation based on microarray datasets

Zhi-Min Deng, Gan-Hong Chen, Fang-Fang Dai, Shi-Yi Liu, Dong-Yong Yang, An-Yu Bao and Yan-Xiang Cheng

PLOS ONE, 2022, vol. 17, issue 4, 1-13

Abstract: Previous work has demonstrated that the expression of microRNA-21 (miR-21) is implicated in cervical cancer (CC). However, little is known regarding its associations with clinical parameters. We first conducted a meta-analysis using data from Gene Expression Omnibus (GEO) microarrays and The Cancer Genome Atlas (TCGA). Then, enrichment analysis and hub gene screening were performed by bioinformatic methods. Finally, the role of the screened target genes in CC was explored. According to the meta-analysis, the expression of miR-21 in cancer tissues was higher than in adjacent nontumor tissues (P

Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0267108

DOI: 10.1371/journal.pone.0267108

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