Antibiotic prophylaxis for percutaneous nephrolithotomy: An updated systematic review and meta-analysis

Hae Do Jung, Kang Su Cho, Young Joon Moon, Doo Yong Chung, Dong Hyuk Kang and Joo Yong Lee

PLOS ONE, 2022, vol. 17, issue 4, 1-12

Abstract: Introduction: A single dose of preventive antibiotics is known to be sufficient to reduce the rate of infection-related complications in percutaneous nephrolithotomy (PCNL). However, some studies reported that the extended dose showed lower complications for high-risk groups. Therefore, we performed a systematic review and meta-analysis comparing single- and extended-dose antibiotic prophylaxis for PCNL. Materials and methods: Relevant studies that compared single- and extended-dose antibiotic prophylactic therapies were identified. Articles were selected from PubMed, EMBASE, KoreaMed, and Google Scholar up to September 2021. Fever and systemic inflammatory response syndrome (SIRS) were compared by meta-analysis. A subgroup analysis was performed according to the degree of risk to the patient. Results: A total of 10 articles were included in this study. There were no significant differences between single dose and extended dose in the rate of fever [p = 0.93, OR = 0.96, 95% confidence interval (CI) 0.44–2.13, I2 = 64%]. Extended dose showed lower rate of SIRS compared to single dose (p = 0.0005, OR = 1.81, 95% CI 1.30–2.53, I2 = 53%); in the subgroup analysis, extended dose also showed lower rates of SIRS compared to single dose in high-risk patients (p

Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0267233

DOI: 10.1371/journal.pone.0267233

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