Single-cell measurement quality in bits

Jayan Rammohan, Swarnavo Sarkar and David Ross

PLOS ONE, 2022, vol. 17, issue 8, 1-14

Abstract: Single-cell measurements have revolutionized our understanding of heterogeneity in cellular response. However, there is no universally comparable way to assess single-cell measurement quality. Here, we show how information theory can be used to assess and compare single-cell measurement quality in bits, which provides a universally comparable metric for information content. We anticipate that the experimental and theoretical approaches we show here will generally enable comparisons of quality between any single-cell measurement methods.

Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0269272

DOI: 10.1371/journal.pone.0269272

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