Association between urinary biomarkers MMP-7/TIMP-2 and reduced renal function in children with ureteropelvic junction obstruction

Hsin-Hsiao S Wang, Patricia S Cho, Hui Zhi, Stephen A Kostel, Shannon DiMartino, Adelle M Dagher, Kylie H Davis, Lily D Cabour, Ashley Shimmel, James Lee, John W Froehlich, David Zurakowski, Marsha A Moses and Richard S Lee

PLOS ONE, 2022, vol. 17, issue 7, 1-11

Abstract: Importance: Extracellular matrix proteins and enzymes involved in degradation have been found to be associated with tissue fibrosis and ureteropelvic junction obstruction (UPJO). In this study we developed a promising urinary biomarker model which can identify reduced renal function in UPJ obstruction patients. This can potentially serve as a non-invasive way to enhance surgical decision making for patients and urologists. Objective: We sought to develop a predictive model to identify UPJO patients at risk for reduced renal function. Design: Prospective cohort study Setting: Pre-operative urine samples were collected in a prospectively enrolled UPJO biomarker registry at our institution. Urinary MMP-2, MMP-7, TIMP-2, and NGAL were measured as well as clinical characteristics including hydronephrosis grade, differential renal function, t1/2, and UPJO etiology. Participants: Children who underwent pyeloplasty for UPJO Main outcome measurement: Primary outcome was reduced renal function defined as MAG3 function

Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0270018

DOI: 10.1371/journal.pone.0270018

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