The effect of acupuncture on oxidative stress: A systematic review and meta-analysis of animal models

Yu Zhao, Bo Zhou, Guangyin Zhang, Shixin Xu, Jipeng Yang, Shizhe Deng, Zengmin Yao, Qiang Geng, Bin Ouyang and Tian Xia

PLOS ONE, 2022, vol. 17, issue 9, 1-16

Abstract: Introduction: Oxidative stress is involved in the occurrence and development of multiple diseases. Acupuncture shows an excellent clinical efficacy in practical application but its mechanism remains unclear. This systematic review and meta-analysis was aimed at assessing the effect of acupuncture on oxidative stress in animal models. Methods: PubMed, Embase, and Web of Science database were retrieved for randomized controlled trials about acupuncture on oxidative stress in animal models from inception to August 2021. Two reviewers independently screened and extracted articles according to inclusion and exclusion criteria. We used the mean difference (MD)/standardized mean difference (SMD) to perform an effect size analysis and selected fixed-effect or random-effect models to pool the data, depending on a 95% confidence interval (CI). Results: A total of 12 studies comprising 125 samples were included in the quantitative meta-analysis. Compared with sham acupuncture, acupuncture (manual acupuncture, electropuncture, and laser acupuncture) reduced the level of malondialdehyde (SMD, −3.03; CI, −4.40, −1.65; p

Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0271098

DOI: 10.1371/journal.pone.0271098

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