The effect of Cyclophilin D depletion on liver regeneration following associating liver partition and portal vein ligation for staged hepatectomy

Noemi Daradics, Gergo Horvath, Laszlo Tretter, Agnes Paal, Andras Fulop, Andras Budai and Attila Szijarto

PLOS ONE, 2022, vol. 17, issue 7, 1-15

Abstract: Aim: Associating Liver Partition and Portal vein ligation for Staged hepatectomy (ALPPS) is a modification of two-stage hepatectomy profitable for patients with inoperable hepatic tumors by standard techniques. Unfortunately, initially poor postoperative outcome was associated with ALPPS, in which mitochondrial dysfunction played an essential role. Inhibition of cyclophilins has been already proposed to be efficient as a mitochondrial therapy in liver diseases. To investigate the effect of Cyclophilin D (CypD) depletion on mitochondrial function, biogenesis and liver regeneration following ALPPS a CypD knockout (KO) mice model was created. Methods: Male wild type (WT) (n = 30) and CypD KO (n = 30) mice underwent ALPPS procedure. Animals were terminated pre-operatively and 24, 48, 72 or 168 h after the operation. Mitochondrial functional studies and proteomic analysis were performed. Regeneration rate and mitotic activity were assessed. Results: The CypD KO group displayed improved mitochondrial function, as both ATP production (P

Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0271606

DOI: 10.1371/journal.pone.0271606

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