Combination of PI-RADS score and mRNA urine test—A novel scoring system for improved detection of prostate cancer

Olga Katzendorn, Christoph A J von Klot, Samy Mahjoub, Pouriya Faraj Tabrizi, Nina N Harke, Hossein Tezval, Susanne Hellms, Jörg Hennenlotter, Mirza S Baig, Arnulf Stenzl, Ferdinand Seith, Marcel Lafos, Markus A Kuczyk, Steffen Rausch and Inga Peters

PLOS ONE, 2022, vol. 17, issue 8, 1-11

Abstract: Available tests to detect clinically significant prostate cancer frequently lead to overdiagnosis and overtreatment. Our study assessed the feasibility of combining a urinary biomarker-based risk score (SelectMDx®) and multiparametric MRI outcomes in order to identify patients with prostate cancer on prostate biopsy with increased accuracy and reliability. Samples of 74 men with suspicion of prostate cancer and available multiparametric MRI were analysed in a prospective cross-sectional study design. First-voided urine for determination of HOXC6 and DLX1 mRNA levels was collected after digital rectal examination and prior to MRI/ultrasound fusion-guided prostate biopsy. All multiparametric MRI images were centrally reviewed by two experienced radiologists blinded for urine test results and biopsy outcome. The PI-RADS v2 was used. SelectMDx® score, PI-RADS and Gleason Sore were obtained. Associations between Gleason Score, PI-RADS scores and SelectMDx® were assessed using ANOVA and t-test. Sensitivity and specificity were assessed and evaluated as area-under-the-curve of the receiver operating characteristic. Upon biopsy, 59.5% of patients were diagnosed with prostate cancer, whereby 40.6% had high-grade prostate cancer (GS ≥ 7a). SelectMDx® scores were significantly higher for patients with positive biopsy findings (49.07 ± 25.99% vs. 22.00 ± 26.43%; p

Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0271981

DOI: 10.1371/journal.pone.0271981

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