The impact of retinal fluid tolerance on the outcomes of neovascular age-related macular degeneration treated using aflibercept: A real-world study

Yu-Ting Jeng, Tso-Ting Lai, Chao-Wen Lin, Ta-Ching Chen, Yi-Ting Hsieh, Chang-Ping Lin, Tzyy-Chang Ho, Chung-May Yang and Chang-Hao Yang

PLOS ONE, 2022, vol. 17, issue 7, 1-14

Abstract: This study investigated the impact of retinal fluid tolerance on retinal thickness and visual acuity in patients with neovascular age-related macular degeneration after 18 months of treatment using intravitreal aflibercept. This retrospective study was based on the medical records of 90 eyes presenting persistent or recurrent retinal fluid retention after 3 months of aflibercept loading injections. We defined the fluid tolerance ratio as the sum of fluid-tolerance duration divided by the total duration of retinal fluid observed throughout the follow-up period. Eyes were categorized into strict, intermediate, and relaxed group based on their fluid tolerance ratio (= 0, = 30%, respectively). The mean total follow-up time was 556 days. The relaxed group required fewer injections than the strict group (4.92 vs 7.50 injections, P

Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0271999

DOI: 10.1371/journal.pone.0271999

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