Associations between fully-automated, 3D-based functional analysis of the left atrium and classification schemes in atrial fibrillation

Maurice Pradella, Constantin Anastasopoulos, Shan Yang, Manuela Moor, Patrick Badertscher, Julian E Gehweiler, Florian Spies, Philip Haaf, Michael Zellweger, Gregor Sommer, Bram Stieltjes, Jens Bremerich, Stefan Osswald, Michael Kühne, Christian Sticherling and Sven Knecht

PLOS ONE, 2022, vol. 17, issue 8, 1-19

Abstract: Background: Atrial fibrillation (AF) has been linked to left atrial (LA) enlargement. Whereas most studies focused on 2D-based estimation of static LA volume (LAV), we used a fully-automatic convolutional neural network (CNN) for time-resolved (CINE) volumetry of the whole LA on cardiac MRI (cMRI). Aim was to investigate associations between functional parameters from fully-automated, 3D-based analysis of the LA and current classification schemes in AF. Methods: We retrospectively analyzed consecutive AF patients who underwent cMRI on 1.5T systems including a stack of oblique-axial CINE series covering the whole LA. The LA was automatically segmented by a validated CNN. In the resulting volume-time curves, maximum, minimum and LAV before atrial contraction were automatically identified. Active, passive and total LA emptying fractions (LAEF) were calculated and compared to clinical classifications (AF Burden score (AFBS), increased stroke risk (CHA2DS2VASc≥2), AF type (paroxysmal/persistent), EHRA score, and AF risk factors). Moreover, multivariable linear regression models (mLRM) were used to identify associations with AF risk factors. Results: Overall, 102 patients (age 61±9 years, 17% female) were analyzed. Active LAEF (LAEF_active) decreased significantly with an increase of AFBS (minimal: 44.0%, mild: 36.2%, moderate: 31.7%, severe: 20.8%, p

Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0272011

DOI: 10.1371/journal.pone.0272011

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