Psychological interventions to prevent relapse in anxiety and depression: A systematic review and meta-analysis

Esther Krijnen- de Bruin, Willemijn Scholten, Anna Muntingh, Otto Maarsingh, Berno van Meijel, Annemieke van Straten and Neeltje Batelaan

PLOS ONE, 2022, vol. 17, issue 8, 1-20

Abstract: Objectives: The aim of this review is to establish the effectiveness of psychological relapse prevention interventions, as stand-alone interventions and in combination with maintenance antidepressant treatment (M-ADM) or antidepressant medication (ADM) discontinuation for patients with remitted anxiety disorders or major depressive disorders (MDD). Methods: A systematic review and a meta-analysis were conducted. A literature search was conducted in PubMed, PsycINFO and Embase for randomised controlled trials (RCTs) comparing psychological relapse prevention interventions to treatment as usual (TAU), with the proportion of relapse/recurrence and/or time to relapse/recurrence as outcome measure. Results: Thirty-six RCTs were included. During a 24-month period, psychological interventions significantly reduced risk of relapse/recurrence for patients with remitted MDD (RR 0.76, 95% CI: 0.68–0.86, p

Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0272200

DOI: 10.1371/journal.pone.0272200

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