Development of a checklist of standard items for processing individual participant data from randomised trials for meta-analyses: Protocol for a modified e-Delphi study

Kylie E Hunter, Angela C Webster, Mike Clarke, Matthew J Page, Sol Libesman, Peter J Godolphin, Mason Aberoumand, Larysa H M Rydzewska, Rui Wang, Aidan C Tan, Wentao Li, Ben W Mol, Melina Willson, Vicki Brown, Talia Palacios and Anna Lene Seidler

PLOS ONE, 2022, vol. 17, issue 10, 1-10

Abstract: Individual participant data meta-analyses enable detailed checking of data quality and more complex analyses than standard study-level synthesis of summary data based on publications. However, there is limited existing guidance on the specific systematic checks that should be undertaken to confirm and enhance data quality for individual participant data meta-analyses and how to conduct these checks. We aim to address this gap by developing a checklist of items for data quality checking and cleaning to be applied to individual participant data meta-analyses of randomised trials. This study will comprise three phases: 1) a scoping review to identify potential checklist items; 2) two e-Delphi survey rounds among an invited panel of experts followed by a consensus meeting; and 3) pilot testing and refinement of the checklist, including development of an accompanying R-markdown program to facilitate its uptake.

Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0275893

DOI: 10.1371/journal.pone.0275893

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