Invariant structural and functional brain regions associated with tinnitus: A meta-analysis

John C Moring, Fatima T Husain, Jodie Gray, Crystal Franklin, Alan L Peterson, Patricia A Resick, Amy Garrett, Carlos Esquivel and Peter T Fox

PLOS ONE, 2022, vol. 17, issue 10, 1-17

Abstract: Tinnitus is a common, functionally disabling condition of often unknown etiology. Neuroimaging research to better understand tinnitus is emerging but remains limited in scope. Voxel-based physiology (VBP) studies detect tinnitus-associated pathophysiology by group-wise contrast (tinnitus vs controls) of resting-state indices of hemodynamics, metabolism, and neurovascular coupling. Voxel-based morphometry (VBM) detects tinnitus-associated neurodegeneration by group-wise contrast of structural MRI. Both VBP and VBM studies routinely report results as atlas-referenced coordinates, suitable for coordinate-based meta-analysis (CBMA). Here, 17 resting-state VBP and 8 VBM reports of tinnitus-associated regional alterations were meta-analyzed using activation likelihood estimation (ALE). Acknowledging the need for data-driven insights, ALEs were performed at two levels of statistical rigor: corrected for multiple comparisons and uncorrected. The corrected ALE applied cluster-level inference thresholding by intensity (z-score > 1.96; p

Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0276140

DOI: 10.1371/journal.pone.0276140

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