Association between XRCC3 p.Thr241Met polymorphism and risk of glioma: A systematic review and meta-analysis

Shing Cheng Tan, Teck Yew Low, Hafiz Muhammad Jafar Hussain, Mohamad Ayub Khan Sharzehan, Hilary Sito, Hamed Kord-Varkaneh and Md Asiful Islam

PLOS ONE, 2022, vol. 17, issue 10, 1-15

Abstract: Background: The XRCC3 p.Thr241Met (rs861539) polymorphism has been extensively studied for its association with glioma risk, but results remain conflicting. Therefore, we performed a systematic review and meta-analysis to resolve this inconsistency. Methods: Studies published up to June 10, 2022, were searched in PubMed, Web of Science, Scopus, VIP, Wanfang, and China National Knowledge Infrastructure databases and screened for eligibility. Then, the combined odds ratio (OR) of the included studies was estimated based on five genetic models, i.e., homozygous (Met/Met vs. Thr/Thr), heterozygous (Thr/Met vs. Thr/Thr), dominant (Thr/Met + Met/Met vs. Thr/Thr), recessive (Met/Met vs. Thr/Thr + Thr/Met) and allele (Met vs. Thr). The study protocol was preregistered at PROSPERO (registration number: CRD42021235704). Results: Overall, our meta-analysis of 14 eligible studies involving 12,905 subjects showed that the p.Thr241Met polymorphism was significantly associated with increased glioma risk in both homozygous and recessive models (homozygous, OR = 1.381, 95% CI = 1.081–1.764, P = 0.010; recessive, OR = 1.305, 95% CI = 1.140–1.493, P 0.05). Conclusion: We demonstrated that the XRCC3 p.Thr241Met polymorphism is associated with an increased risk of glioma only in the homozygous and recessive models.

Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0276313

DOI: 10.1371/journal.pone.0276313

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