Progestogens for maintenance tocolysis in symptomatic women. A systematic review and meta-analysis

Francesca Ferrari, Silvia Minozzi, Laura Basile, Giuseppe Chiossi and Fabio Facchinetti

PLOS ONE, 2023, vol. 18, issue 2, 1-18

Abstract: Objective: Prevention of preterm birth (PTB) with progestogens after an episode of threatened preterm labour is still controversial. As different progestogens have distinct molecular structures and biological effects, we conducted a systematic review and pairwise meta-analysis to investigate the individual role played by 17-alpha-hydroxyprogesterone caproate (17-HP), vaginal progesterone (Vaginal P) and oral progesterone (Oral P). Methods: The search was performed in MEDLINE, ClinicalTrials.gov and the Cochrane Central Register of Controlled Trials (CENTRAL) up to 31 October 2021. Published RCTs comparing progestogens to placebo or no treatment for maintenance tocolysis were considered. We included women with singleton gestations, excluding quasi-randomized trials, studies on women with preterm premature rupture of membrane, or receiving maintenance tocolysis with other drugs. Primary outcomes were preterm birth (PTB)

Date: 2023
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0277563

DOI: 10.1371/journal.pone.0277563

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