Evaluation of Triclosan coated suture in obstetrical surgery: A prospective randomized controlled study (NCT05330650)

Wael Mbarki, Hajer Bettaieb, Nesrine Souayeh, Idriss Laabidi, Hadhemi Rouis, Soumaya Halouani, Rami Boufarghine, Maha Bouyahia, Rahma Bouhmida, Mariem Ouederni, Anissa Ben Amor, Amal Chermiti, Hadir Laamiri, Amira Lika, Imen Chaibi, Hedhili Oueslati, Najeh Hsayaoui and Chaouki Mbarki

PLOS ONE, 2022, vol. 17, issue 12, 1-10

Abstract: Objectives: To assess the effectiveness of Triclosan coated suture in reducing surgical site infections (SSIs) rate after caesarian delivery (CD). Study design: Three hundred eighty patients were randomly assigned to closure with polyglactin non coated suture VICRYL, or with polyglactin coated suture VICRYL Plus after caesarian section. The primary outcome was the rate of SSIs within 30 days after surgery and secondary outcomes were the rate of wound healing complications. Results: SSI rate was 2.5% in Triclosan group compared to 8.1% with non-coated suture. Use of Triclosan coated suture (TCS) was associated with 69% reduction in SSI rate (p = 0.037; ORa:0.294; 95% CI:0.094–0.921). The use of Triclosan coated suture was associated with statistically lower risk of wound oedema (2.5% vs 10%), (p = 0.019; OR:0.595), dehiscence (3.8% vs 10.6%), (p = 0.023; OR:0.316) and hematoma (p = 0.035; OR:0.423). Conclusion: Our results confirm the effectiveness of Triclosan coated suture in reducing SSI rate and wound healing disturbances. Trial registration: Registered at ClinicalTrials.gov / ID (NCT05330650).

Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0278939

DOI: 10.1371/journal.pone.0278939

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