Association between vitamin D level and respiratory distress syndrome: A systematic review and meta-analysis

Yoo Jinie Kim, Gina Lim, Ran Lee, Sochung Chung, Jae Sung Son and Hye Won Park

PLOS ONE, 2023, vol. 18, issue 1, 1-12

Abstract: Background: Growing evidence suggests an association between the vitamin D levels and respiratory outcomes of preterm infants. The objective of this systematic review and meta-analysis was to explore whether premature neonates with a vitamin D deficiency have an increased risk of respiratory distress syndrome (RDS). Methods: We searched PubMed, EMBASE, and the Cochrane Library up through July 20, 2021. The search terms were ‘premature infant’, ‘vitamin D’, and ‘respiratory distress syndrome’. We retrieved randomized controlled trials and cohort and case-control studies. For statistical analysis, we employed the random-effects model in Comprehensive Meta-Analysis Software ver. 3.3. We employed the Newcastle-Ottawa Scales for quality assessment of the included studies. Results: A total of 121 potentially relevant studies were found, of which 15 (12 cohort studies and 3 case-control studies) met the inclusion criteria; the studies included 2,051 preterm infants. We found significant associations between RDS development in such infants and vitamin D deficiency within 24 h of birth based on various criteria, thus vitamin D levels

Date: 2023
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0279064

DOI: 10.1371/journal.pone.0279064

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