Validation of the motion sickness severity scale: Secondary analysis of a randomized, double-blind, placebo-controlled study of a treatment for motion sickness

Mark É Czeisler, Justina M Pruski, Pan Wang, Jingyuan Wang, Changfu Xiao, Mihael H Polymeropoulos and Vasilios M Polymeropoulos

PLOS ONE, 2023, vol. 18, issue 1, 1-14

Abstract: Background: Motion sickness is characterized by nausea and vomiting among a constellation of symptoms. Symptom severity is dynamic and distressing. Most validated motion sickness scales are time-intensive and effortful, with alternative scales having uncertain performance or non-specific measures. A validated instrument allowing for facile, rapid assessment of core motion sickness symptom severity would therefore be valuable. We assessed the performance of the Motion Sickness Severity Scale (MSSS), a six-item questionnaire designed to measure real-time motion sickness symptoms. Methods: MSSS construct validity was assessed as a secondary analysis of data from 63 healthy participants without antiemetic treatment in a clinical trial (Unique Identifier = NCT03772340) conducted to evaluate the safety and efficacy of Tradipitant—a novel neurokinin-1 receptor antagonist—in the treatment of motion sickness. Clinical outcome assessments included the MSSS, the Patient Global Impression of Severity (PGI-S), and the Motion Sickness Assessment Questionnaire (MSAQ). The performance of the MSSS through Pearson correlation coefficients, within-group analysis of variance, empirical cumulative distribution functions, and Kolmogorov-Smirnov tests. Results: The MSSS correlated very highly with the PGI-S (r = 0.93, p-value

Date: 2023
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0280058

DOI: 10.1371/journal.pone.0280058

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