Social isolation as a risk factor for all-cause mortality: Systematic review and meta-analysis of cohort studies

Ryo Naito, Martin McKee, Darryl Leong, Shrikant Bangdiwala, Sumathy Rangarajan, Shofiqul Islam and Salim Yusuf

PLOS ONE, 2023, vol. 18, issue 1, 1-16

Abstract: Background: Although several epidemiological studies have linked social isolation to increased risk of mortality, the magnitude of any effect is unclear, in part because of the use of different measures of social isolation. Objective: To examine the association between social isolation and all-cause mortality and investigate whether it differs in various subgroups or populations. Data sources: We searched for relevant studies in electronic databases: MEDLINE (1946 to December 31, 2021), EMBASE (1974 to December 31, 2021), and PsycINFO (1806 to December 31, 2021). Selection criteria: We included both prospective and retrospective cohort studies that examined the association between social isolation and all-cause mortality among adults. Data collection and analysis: Two reviewers screened and extracted data independently. We contacted study authors to obtain missing information whenever possible. Data were pooled using a random effect model to calculate estimates of the effects of social isolation on all-cause mortality. Results: Data from studies involving 1.30 million individuals were included. The pooled hazard ratio of social isolation for all-cause mortality was 1.33 (95% confidence interval; 1.26–1.41, heterogeneity: Chi² = 112.51, P

Date: 2023
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0280308 (text/html)
https://journals.plos.org/plosone/article/file?id= ... 80308&type=printable (application/pdf)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0280308

DOI: 10.1371/journal.pone.0280308

Access Statistics for this article

More articles in PLOS ONE from Public Library of Science
Bibliographic data for series maintained by plosone ().