Apolipoprotein E4 allele is genetically associated with risk of the short- and medium-term postoperative cognitive dysfunction: A meta-analysis and trial sequential analysis

Wei-Jen Hsiao, Chien-Yu Chen, Yi-No Kang, Chaur-Jong Hu, Che-Hong Chen, Pei-Lin Lin and Yu-Cih Lin

PLOS ONE, 2023, vol. 18, issue 2, 1-21

Abstract: The aim of systematic review and meta-analysis was to investigate whether APOE4 was associated with postoperative neurologic dysfunction occurrence in short- or medium-term among surgical patients and to study the potential genetic association among these two entities. We searched electronic databases for reserch studies to evaluate the association of APOE4 with postoperative delirium (POD) or short- and medium term postoperative cognitive dysfunction (POCD). Twenty-two trials (16 prospective and six retrospective) with 6734 patients were included. APOE4 alleles was shown significantly associated with POCD within 1 week (odds ratio, OR, 1.89, 95% confidence interval, CI, 1.36 to 2.6278, p

Date: 2023
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0282214

DOI: 10.1371/journal.pone.0282214

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