Efficacy and safety of tranexamic acid in intracranial haemorrhage: A meta-analysis

Yu Xiong, Xiumei Guo, Xinyue Huang, Xiaodong Kang, Jianfeng Zhou, Chunhui Chen, Zhigang Pan, Linxing Wang, Roland Goldbrunner, Lampis Stavrinou, Pantelis Stavrinou, Shu Lin, Yuping Chen, Weipeng Hu and Feng Zheng

PLOS ONE, 2023, vol. 18, issue 3, 1-13

Abstract: Background: Although some studies have shown that tranexamic acid is beneficial to patients with intracranial haemorrhage, the efficacy and safety of tranexamic acid for intracranial haemorrhage remain controversial. Method: The PubMed, EMBASE, and Cochrane Library databases were systematically searched. The review followed PRISMA guidelines. Data were analyzed using the random-effects model. Results: Twenty-five randomized controlled trials were included. Tranexamic acid significantly inhibited hematoma growth in intracranial hemorrhage (ICH) and traumatic brain injury (TBI) patients. (ICH: mean difference -1.76, 95%CI -2.78 to -0.79, I2 = 0%, P

Date: 2023
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0282726

DOI: 10.1371/journal.pone.0282726

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