Factors correlated with pain after total knee arthroplasty: A systematic review and meta-analysis

Unni Olsen, Maren Falch Lindberg, Christopher Rose, Eva Denison, Caryl Gay, Arild Aamodt, Jens Ivar Brox, Øystein Skare, Ove Furnes, Kathryn A Lee and Anners Lerdal

PLOS ONE, 2023, vol. 18, issue 3, 1-19

Abstract: Main objective: Systematically review and synthesize preoperative and intraoperative factors associated with pain after total knee arthroplasty (TKA) in patients with osteoarthritis. Methods: Based on a peer-reviewed protocol, we searched Medline, Embase, CINAHL, Cochrane Library, and PEDro for prospective observational studies (January 2000 to February 2023) investigating factors associated with pain after TKA. The primary outcome was pain twelve months after TKA. Pain at three and six months were secondary outcomes. Multivariate random-effects meta-analyses were used to estimate mean correlation (95% CIs) between factors and pain. Sensitivity analysis was performed for each risk of bias domain and certainty of evidence was assessed. Results: Of 13,640 studies, 29 reports of 10,360 patients and 61 factors were analysed. The mean correlation between preoperative factors and more severe pain at twelve months was estimated to be 0.36 (95% CI, 0.24, 0.47; P

Date: 2023
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0283446

DOI: 10.1371/journal.pone.0283446

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