Outcomes and clinical implications of intranasal insulin on cognition in humans: A systematic review and meta-analysis

Sally Wu, Nicolette Stogios, Margaret Hahn, Janani Navagnanavel, Zahra Emami, Araba Chintoh, Philip Gerretsen, Ariel Graff-Guerrero, Tarek K Rajji, Gary Remington and Sri Mahavir Agarwal

PLOS ONE, 2023, vol. 18, issue 6, 1-14

Abstract: Background: Aberrant brain insulin signaling has been posited to lie at the crossroads of several metabolic and cognitive disorders. Intranasal insulin (INI) is a non-invasive approach that allows investigation and modulation of insulin signaling in the brain while limiting peripheral side effects. Objectives: The objective of this systematic review and meta-analysis is to evaluate the effects of INI on cognition in diverse patient populations and healthy individuals. Methods: MEDLINE, EMBASE, PsycINFO, and Cochrane CENTRAL were systematically searched from 2000 to July 2021. Eligible studies were randomized controlled trials that studied the effects of INI on cognition. Two independent reviewers determined study eligibility and extracted relevant descriptive and outcome data. Results: Twenty-nine studies (pooled N = 1,726) in healthy individuals as well as those with Alzheimer’s disease (AD)/mild cognitive impairment (MCI), mental health disorders, metabolic disorders, among others, were included in the quantitative meta-analysis. Patients with AD/MCI treated with INI were more likely to show an improvement in global cognition (SMD = 0.22, 95% CI: 0.05–0.38 p =

Date: 2023
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0286887 (text/html)
https://journals.plos.org/plosone/article/file?id= ... 86887&type=printable (application/pdf)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0286887

DOI: 10.1371/journal.pone.0286887

Access Statistics for this article

More articles in PLOS ONE from Public Library of Science
Bibliographic data for series maintained by plosone ().