Analysis of clozapine-induced seizures using the Japanese Adverse Drug Event Report database

Masakazu Hatano, Kaho Yamada, Haruna Matsuzaki, Rina Yokoi, Takeo Saito and Shigeki Yamada

PLOS ONE, 2023, vol. 18, issue 6, 1-10

Abstract: Among antipsychotics, clozapine is associated with a high risk of seizures. This study aimed to generate novel hypotheses regarding trends in the onset of clozapine-induced seizures using the JADER (Japanese Adverse Drug Event Report) database. Seizures were defined according to the Standardized MedDRA Queries (SMQ) for convulsions (SMQ20000079). Trends in the onset of clozapine-induced seizures were assessed using multivariate logistic regression analysis with covariates of sex, age, clozapine dose, antipsychotic polypharmacy, concomitant medications, and history of convulsive disorder. In addition, we assessed the time-to-onset of clozapine-induced seizures using the median time, interquartile range, and Weibull shape parameter. The JADER database registered 2,745 cases of adverse events with clozapine, and 1,784 cases were included in the analysis after excluding cases for which clinical information was not available. Medium (200–400 mg) and high (> 400 mg) doses of clozapine had a significantly higher reporting rate of seizures than low doses (

Date: 2023
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0287122

DOI: 10.1371/journal.pone.0287122

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