Comparison of monocyte distribution width and Procalcitonin as diagnostic markers for sepsis: Meta-analysis of diagnostic test accuracy studies

Karam R Motawea, Samah S. Rozan, Nesreen Elsayed Talat, Rowan H. Elhalag, Sarraa Mohammed Reyad, Pensée Chebl, Sarya Swed, Bisher Sawaf, Hadeel Hadeel Alfar, Amr Farwati, Bana Sabbagh, Esperance M. Madera, Amro El Metaafy, Joshuan J. Barboza, Ranjit Sah and Hani Aiash

PLOS ONE, 2023, vol. 18, issue 8, 1-15

Abstract: Aim: We aimed to perform a meta-analysis to find out whether PCT and MDW could be used as accurate diagnostic markers for sepsis. Methods: We searched PUBMED, WOS, and SCOPUS databases. Inclusion criteria were any observational or clinical trials that compared monocyte Distribution Width [MDW] with Procalcitonin [PCT] as diagnostic markers in a patient with sepsis. Case reports, editorials, conference abstracts, and animal studies were excluded. RevMan software [5.4] was used to perform the meta-analysis. Results: After the complete screening, 5 observational studies were included in the meta-analysis. The total number of patients included in the meta-analysis in the sepsis group is 565 and 781 in the control group. The pooled analysis between the sepsis group and controls showed a statistically significant association between sepsis and increased levels of MDW and PCT [MD = 3.94, 95% CI = 2.53 to 5.36, p-value the overall ROC Area for PCT [0.760]. Conclusion: Our study revealed a statistically significant association between sepsis and increased MDW and PCT levels compared with controls and the overall ROC Area for MDW is higher than the overall ROC Area for PCT, indicating that the diagnostic accuracy of MDW is higher than PCT.MDW can be used as a diagnostic marker for sepsis patients in the emergency department. More multicenter studies are needed to support our findings.

Date: 2023
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0288203

DOI: 10.1371/journal.pone.0288203

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