Effects of fecal microbiota transplantation in metabolic syndrome: A meta-analysis of randomized controlled trials

Bo Qiu, JiaXu Liang and Cong Li

PLOS ONE, 2023, vol. 18, issue 7, 1-16

Abstract: Objective: The prevalence of obesity and type 2 diabetes is rapidly increasing worldwide, posing serious threats to human health. This study aimed to evaluate the role of FMT in the treatment of obesity and/or metabolic syndrome and its impact on clinically important parameters. Methods: We searched Medline, Embase, and Cochrane Library databases up to April 31, 2022 and further assessed articles that met the eligibility criteria. Mean differences and 95% confidence intervals were used to analyze continuous data. The I2 statistic was used to measure study heterogeneity. Univariate meta-regression or subgroup analyses were performed to explore the covariates that might contribute to heterogeneity. Potential publication bias was assessed using the Egger’s test. We used the GRADEpro guideline development tool to assess the quality of the evidence. Results: Nine studies, comprising 303 participants, were included in the meta-analysis. In the short-term outcomes (

Date: 2023
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0288718

DOI: 10.1371/journal.pone.0288718

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