Influence of gadolinium, field-strength and sequence type on quantified perfusion values in phase-resolved functional lung MRI

Julian Glandorf, Fynn Brunzema, Filip Klimeš, Lea Behrendt, Andreas Voskrebenzev, Marcel Gutberlet, Marius M Wernz, Robert Grimm, Frank Wacker and Jens Vogel-Claussen

PLOS ONE, 2023, vol. 18, issue 8, 1-14

Abstract: Purpose: The purpose of this study is to evaluate the influences of gadolinium-based contrast agents, field-strength and different sequences on perfusion quantification in Phase-Resolved Functional Lung (PREFUL) MRI. Materials and methods: Four cohorts of different subjects were imaged to analyze influences on the quantified perfusion maps: 1) at baseline and after 2 weeks to obtain the reproducibility (26 COPD patients), 2) before and after the administration of gadobutrol (11 COPD, 2 PAH and 1 asthma), 3) at 1.5T and 3T (12 healthy, 4 CF), and 4) with different acquisition sequences spoiled gradient echo (SPGR) and balanced steady-state free precession (bSSFP) (11 COPD, 7 healthy). Wilcoxon-signed rank test, Bland-Altman plots, voxelwise Pearson correlations, normalized histogram analyses with skewness and kurtosis and two-sample Kolmogorov-Smirnov tests were performed. P value ≤ 0.05 was considered statistically significant. Results: In all cohorts, linear correlations of the perfusion values were significant with correlation coefficients of at least 0.7 considering the entire lung (P

Date: 2023
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0288744

DOI: 10.1371/journal.pone.0288744

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