Causal relationship between body mass index, type 2 diabetes and bone mineral density: Mendelian randomization

Weiwei Ma, Xiaohong Zhou, Xin Huang and Yong Xiong

PLOS ONE, 2023, vol. 18, issue 10, 1-13

Abstract: Objective: To reveal the relationship between Body Mass Index(BMI), type 2 diabetes, and bone mineral density(BMD) using a mendelian randomization (MR) approach. Methods: GWAS data on BMI, type 2 diabetes, and BMD were selected from the IEU GWAS database at the University of Bristol.Univariable, multivariable, and mediated MR analyses were used to explore the relationship between BMI, type 2 diabetes, and BMD. beta(β) values were given, and three methods, including inverse variance weighting, MR-Egger regression, and weighted median, were used in this analysis. Results: Univariable mendelian randomization (UVMR) results showed that BMI and type 2 diabetes were positively associated with BMD. However, the association between BMI and BMD was insignificant in the multivariable Mendelian randomization (MVMR) analysis, while that between type 2 diabetes and BMD remained significant. Mediated MR analysis indicated that type 2 diabetes mediated the regulation of BMD by BMI. Conclusion: This study provides evidence supporting a positive causal association between BMI, type 2 diabetes, and BMD. Type 2 diabetes acts as a mediator in the regulation of BMD by BMI, indicating that both BMI and type 2 diabetes exert a protective influence on BMD.

Date: 2023
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0290530

DOI: 10.1371/journal.pone.0290530

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