Effects of the pre-existing coronary heart disease on the prognosis of COVID-19 patients: A systematic review and meta-analysis

Saikun Wang, Ruiting Zhu, Chengwei Zhang, Yingze Guo, Mengjiao Lv, Changyue Zhang, Ce Bian, Ruixue Jiang, Wei Zhou and Lirong Guo

PLOS ONE, 2023, vol. 18, issue 10, 1-22

Abstract: Although studies have shown severe Coronavirus disease 2019 (COVID-19) outcomes in patients with pre-existing coronary heart disease (CHD), the prognosis of COVID-19 patients with pre-existing CHD remains uncertain primarily due to the limited number of patients in existing studies. This study aimed to investigate the impacts of pre-existing CHD on the prognosis of COVID-19 patients. Five electronic databases were searched for eligible studies. This article focused on cohort and case-control studies involving the prognosis of COVID-19 patients with pre-existing CHD. The meta-analysis was performed using a random effects model. The odds ratios (ORs) and 95% confidence intervals (CIs) were used as valid indicators. The study was registered in PROSPERO with the identifier: CRD42022352853. A total of 81 studies, involving 157,439 COVID-19 patients, were included. The results showed that COVID-19 patients with pre-existing CHD exhibited an elevated risk of mortality (OR = 2.45; 95%CI: [2.04, 2.94], P

Date: 2023
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0292021

DOI: 10.1371/journal.pone.0292021

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