The effect of light therapy on sleep disorders and psychobehavioral symptoms in patients with Alzheimer’s disease: A meta-analysis

Lili Zang, Xiaotong Liu, Yu Li, Jiang Liu, Qiuying Lu, Yue Zhang and Qinghui Meng

PLOS ONE, 2023, vol. 18, issue 12, 1-21

Abstract: Background: Although Alzheimer’s disease (AD) mainly affects cognitive function, it is often accompanied by sleep disorders and psychobehavioral symptoms. These symptoms, including depression, agitation, and psychotic symptoms, are prominent hospitalization causes among patients with AD. Currently, relatively more research exists on light therapy for sleep disorders, while those on psychobehavioral symptoms are gradually increasing. However, no consensus exists on these results because of the vulnerability of light therapy to multiple factors, including light intensity and duration. Thus, further research investigating this aspect is warranted. Objective: To evaluate the efficacy of light therapy in improving sleep disorders and psychobehavioural symptoms in patients with AD. Methods: In this meta-analysis, relevant literature was searched in Embase, the Clinical Trials Registry, Web of Science, PubMed, and the Cochrane Library up to December 2022. Furthermore, a fixed-effects model was used for data analysis. Results: Fifteen randomized controlled trials involving 598 patients with AD were included. In the case of sleep disorders, our meta-analysis revealed that light therapy significantly improved sleep efficiency (MD = −2.42, 95% CI = −3.37 to −1.48, p

Date: 2023
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0293977

DOI: 10.1371/journal.pone.0293977

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