Pubertal timing: A life course pathway linking early life risk to adulthood cardiometabolic health

Maria E Bleil, Bradley M Appelhans, Steven E Gregorich, Robert A Hiatt, Glenn I Roisman and Cathryn Booth-LaForce

PLOS ONE, 2024, vol. 19, issue 3, 1-20

Abstract: Objective: To evaluate a series of prospective life course models testing whether the timing of pubertal development is a pathway through which prepubertal risk factors may influence adulthood cardiometabolic health. Methods: Subjects were 655 female participants in the NICHD Study of Early Child Care and Youth Development (SECCYD) and recent SECCYD 30-year follow-up, the Study of Health in Early and Adult Life (SHINE). Prepubertal risk factors included maternal menarcheal age, child race/ethnicity, child health status indicators, and child adversity indicators. Pubertal timing was indexed by breast development onset (Tanner stage [TS] II), pubic hair onset (TS II) and menarcheal age. Adulthood cardiometabolic risk (CMR) was indexed by a composite of waist circumference, systolic blood pressure, diastolic blood pressure, hemoglobin A1c, C-reactive protein, and high-density lipoprotein. Results: Inspection of paths between the prepubertal risk factors, pubertal timing indicators, and adulthood CMR composite showed later breast development onset (-0.173, p

Date: 2024
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0299433

DOI: 10.1371/journal.pone.0299433

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