Effects of fecal microbiota transfer on blood pressure in animal models: A systematic review and meta-analysis

Lingyu Lin, Shurong Xu, Meiling Cai, Sailan Li, Yaqin Chen, Liangwan Chen and Yanjuan Lin

PLOS ONE, 2024, vol. 19, issue 4, 1-16

Abstract: Background: Numerous recent studies have found a strong correlation between intestinal flora and the occurrence of hypertension. However, it remains unclear whether fecal microbiota transfer might affect the blood pressure of the host. This study aimed to quantify both associations. Methods: An electronic search was conducted in PubMed, EMBASE, Cochrane Library, Web of Science, China National Knowledge Infrastructure (CNKI), WanFang database, Weipu, Embase, and SinoMed to retrieve relevant studies. The final search was completed on August 22, 2022. Two authors independently applied the inclusion criteria, extracted data, and assessed the risk of bias assessment. All data were analyzed using RevMan 5.4. Results: A total of 5 articles were selected for final inclusion. All studies were assessed as having a high risk of bias according to the SYRCLE risk of bias tool. The meta-analysis results showed that transplantation of fecal bacteria from the hypertensive model can significantly improve the host’s systolic pressure (MD = 18.37, 95%CI: 9.74~26.99, P

Date: 2024
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0300869

DOI: 10.1371/journal.pone.0300869

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