Taste dysfunction as a predictor of depression in schizophrenia: A systematic review and meta-analysis

Jia Liu, Shu-Jie Sun, Ye Lu, Xin Ping, Wan Zhang and Lin Pei

PLOS ONE, 2024, vol. 19, issue 3, 1-23

Abstract: Objective: This study aims to investigate the relationship between taste dysfunction and depression among patients with schizophrenia, to achieve early detection of depression in clinical practice. Methods: Following PRISMA guidance, a comprehensive literature search was conducted globally, covering papers published from 1961 to June 2023. A total of 17 manuscripts were selected through meta-analysis and sensitivity analysis after examining available materials from seven databases to determine the correlation between depression and taste dysfunction. Results: The comparison of the 17 selected manuscripts revealed that individuals with gustatory dysfunction may be more likely to experience depressive symptoms (SMD, 0.51, 95% CI, 0.08 to 0.93, p = 0.02). Depression is associated with taste dysfunction in certain aspects, as indicated by the pleasantness ratings of sucrose solutions (SMD, -0.53, 95% confidence interval [CI] -1.11 to 0.05, p = 0.08), gustatory identification ability (SMD, 0.96, 95% CI, 0.03 to 1.89, p = 0.04), and the perception threshold of sweet taste (MD, 0.80, 95% CI, 0.79 to 0.81, p

Date: 2024
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0300935

DOI: 10.1371/journal.pone.0300935

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