The impact of sarcopenia on the incidence of postoperative outcomes following spine surgery: Systematic review and meta-analysis

Mingjiang Luo, Zubing Mei, Siliang Tang, Jinshan Huang, Kun Yuan, Lingling Jiang, Zhifeng Tang, Keni Li, Mingxuan Su, Can Su, Yuxin Shi, Zihan Zhang, Jiang Chen, Yuan Zheng, Peng Bin, Zhengbing Yuan, Guosong Xu and Zhihong Xiao

PLOS ONE, 2024, vol. 19, issue 8, 1-21

Abstract: Purpose: Sarcopenia is considered to be an important predictor of adverse outcomes following spinal surgery, but the specific relationship between the two is not clear. The purpose of this meta-analysis is to systematically review all relevant studies to evaluate the impact of sarcopenia on spinal surgery outcomes. Methods: We systematically searched PubMed, Embase and the Cochrane Library for relevant articles published on or before January 9, 2023. The pooled odds ratio (OR) with 95% confidence intervals (CIs) was calculated in a random effects meta-analysis. The main outcome was the risk of adverse outcomes after spinal surgery, including adverse events and mortality. This systematic review and meta-analysis was conducted following the PRISMA guidelines to evaluate the impact of sarcopenia on spinal surgery outcomes. In addition, we also conducted a subgroup analysis and leave-one-out sensitivity analyses to explore the main sources of heterogeneity and the stability of the results. Results: Twenty-four cohort studies, with a total of 243,453 participants, met the inclusion criteria. The meta-analysis showed that sarcopenia was significantly associated with adverse events (OR 1.63, 95% CI 1.17–2.27, P

Date: 2024
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0302291

DOI: 10.1371/journal.pone.0302291

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