Efficacy and safety of herbal medicine combined with acupuncture in pediatric epilepsy treatment: A meta-analysis of randomized controlled trials

Hong-Wen Su, Hsiao-Tien Chen, Chia-Li Kao, Kuo-Chuan Hung, Yao-Tsung Lin, Ping-Hsin Liu, Chien-Ming Lin and I-Wen Chen

PLOS ONE, 2024, vol. 19, issue 5, 1-20

Abstract: Objective: To evaluate the efficacy and safety of herbal medicine and acupuncture combination for pediatric epilepsy treatment. Methods: Databases were searched from their interception until October 2023 to identify randomized controlled trials focusing on the therapeutic efficacy of herbal medicine-acupuncture combination (intervention group) for pediatric epilepsy. The primary outcome was the risk of treatment failure, whereas the secondary outcomes included the risk of post-treatment electroencephalogram (EEG) abnormalities and adverse events. Subgroup analyses were conducted based on the type of herbal compound formulas. Meta-regression analysis was conducted to examine the influence of patient demographics and clinical history on the therapeutic efficacy of herbal medicine-acupuncture combination for pediatric epilepsy. To assess the cumulative evidence, trial sequential analysis (TSA) was performed. Results: The analysis included 10 trials involving a total of 882 pediatric patients. Meta-analysis revealed that the intervention group had a lower risk of treatment failure than the control group (risk ratio [RR] = 0.3, 95% confidence interval [CI]: 0.19–0.47, P

Date: 2024
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0303201

DOI: 10.1371/journal.pone.0303201

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