Association between executive functions and COMT Val108/158Met polymorphism among healthy younger and older adults: A preliminary study

Zoltan Apa, Jessica Gilsoul, Vinciane Dideberg and Fabienne Collette

PLOS ONE, 2024, vol. 19, issue 5, 1-19

Abstract: Background and objectives: Genetic variability in the dopaminergic system could contribute to age-related impairments in executive control. In this study, we examined whether genetic polymorphism for catechol-O-methyltransferase (COMT Val158Met) is related to performance on updating, shifting and inhibition tasks. Methods: We administered a battery of executive tasks assessing updating, shifting and inhibition functions to 45 older and 55 younger healthy participants, and created composite z-scores associated to each function. Six groups were created based on genetic alleles (Val/Val, Val/Met, Met/Met) derived from the COMT gene and age (younger, older). Age and genotype effects were assessed with t-test and ANOVA (p

Date: 2024
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0303343

DOI: 10.1371/journal.pone.0303343

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