A META analysis and systematic review of the effects of exercise interventions on middle-aged and elderly patients with depression

Zheng Zhang, Jia-Yun Liu, Kai-Tuo Zhu and Gui-Quan Huo

PLOS ONE, 2025, vol. 20, issue 1, 1-23

Abstract: Objective: This study sought to conduct a meticulous systematic review, delving into the efficacy of exercise interventions on depressive symptoms among middle-aged and older adults. Additionally, we aimed to scrutinize the nuanced influence of various intervention factors on the intricate relationship between exercise and depressive symptoms within this demographic. Methods: Our investigation involved an extensive search across multiple databases, including PubMed, Embase, Web of Science, and the Cochrane Library, spanning from the inception of these repositories to December 2023. Following a rigorous screening process, we identified and included 12 papers, encompassing a total of 994 subjects. Results: The meta-analysis unveiled a compelling overall effect size of exercise interventions on depressive symptoms in middle-aged and older individuals, represented by SMD = -0.41, with a 95% confidence interval of [-0.60, -0.22], and P

Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0303594

DOI: 10.1371/journal.pone.0303594

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