Role of cell-free DNA levels in the diagnosis and prognosis of sepsis and bacteremia: A systematic review and meta-analysis

Mohammad Najm Dadam, Le Thanh Hien, Engy M Makram, Lam Vinh Sieu, Ahmad Morad, Nada Khalil, Linh Tran, Abdelrahman M Makram and Nguyen Tien Huy

PLOS ONE, 2024, vol. 19, issue 8, 1-16

Abstract: Background: Sepsis remains a major cause of mortality in intensive care units (ICUs). Prompt diagnosis and effective management are imperative for better outcomes. In this systematic review and meta-analysis, we explore the potential of circulating cell-free DNA (cfDNA), as a promising tool for early sepsis detection and prognosis assessment, aiming to address limitations associated with traditional diagnostic methods. Methods: Following PRISMA guidelines, we collected relevant literature from thirteen databases. Studies were included if they analyzed quantitative diagnostic or prognostic cfDNA levels in humans in case of sepsis. We collected data on basic study characteristics, baseline patient demographics (e.g. age and sex), and cfDNA levels across different stages of sepsis. Pooled SMD with 95%-CI was calculated, and Comprehensive Meta-Analysis (CMA) software facilitated meta-analysis. Receiver operating characteristic (ROC) curves were generated to assess cfDNA’s combined sensitivity and specificity in diagnostics and prognostics. Results: We included a final of 44 studies, of which, only 32 with 2950 participants were included in the meta-analysis. cfDNA levels were higher in septic patients compared to healthy controls (SMD = 3.303; 95%-CI [2.461–4.145], p

Date: 2024
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0305895

DOI: 10.1371/journal.pone.0305895

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