An international study to investigate and optimise the safety of discontinuing valproate in young men and women with epilepsy: Protocol

Gashirai K Mbizvo, Glen P Martin, Matthew Sperrin, Laura J Bonnett, Pieta Schofield, Iain Buchan, Gregory Y H Lip and Anthony G Marson

PLOS ONE, 2024, vol. 19, issue 8, 1-10

Abstract: Valproate is the most effective treatment for idiopathic generalised epilepsy. Currently, its use is restricted in women of childbearing potential owing to high teratogenicity. Recent evidence extended this risk to men’s offspring, prompting recommendations to restrict use in everybody aged

Date: 2024
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0306226

DOI: 10.1371/journal.pone.0306226

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