Association between mixed venous oxygen saturation and serum uric acid levels in patients with heart failure

Yuto Mashitani, Kazuo Ogawa, Ryuji Funaki, Yoshiro Tanaka, Takuya Oh, Toshikazu D Tanaka, Tomohisa Nagoshi, Kosuke Minai, Makoto Kawai and Michihiro Yoshimura

PLOS ONE, 2025, vol. 20, issue 2, 1-13

Abstract: Hypoxia leads to increased purine metabolism in tissues, resulting in increased serum uric acid levels, and may also cause impaired uric acid excretion in the kidneys and intestinal tract. However, the relationship between hypoxia and serum uric acid levels in patients with heart failure remains largely unexplored. Because mixed venous oxygen saturation is an acute indicator of systemic oxygenation, in this study, we investigated the relationship between mixed venous oxygen saturation and serum uric acid levels. This retrospective analysis included 386 patients with heart failure who underwent cardiac catheterization at our institution. The relationship between mixed venous oxygen saturation and serum uric acid levels was examined by single regression analysis. Stratified regression analysis, structural equation modeling, and partial correlation analysis were used to examine the effects of eight factors known to influence mixed venous oxygen saturation and serum uric acid levels. The single regression analysis showed a significant negative correlation between mixed venous oxygen saturation and serum uric acid levels (P

Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0306353

DOI: 10.1371/journal.pone.0306353

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