Immunosuppression for adult steroid-dependent or frequently relapsing nephrotic syndrome: A systematic review and meta-analysis

Zhi Yong Wong, Chiu Yee Teo, Yan Qi Fiona Wong, Ka Ting Ng and Soo Kun Lim

PLOS ONE, 2024, vol. 19, issue 7, 1-15

Abstract: Objective: There is limited evidence on which immunosuppressive agents produce the best outcomes for adult patients with steroid-dependent or frequently relapsing nephrotic syndrome (SDNS/FRNS). This review compares the remission rate and adverse effects of various immunosuppressants used. Methods: Studies of adult patients with biopsy-proven SDNS/FRNS, administered any immunosuppressive agents and reported complete remission results as one of the clinical outcomes were included. Articles were independently screened by two researchers. ROBINS-I was used for risk of bias assessment. Random-effects model was used for statistical analysis and corresponding 95% confidence intervals (CIs) were calculated. Results: 574 patients across 28 studies were included in the analysis. Patients receiving rituximab have a complete remission rate of 89% (95% CI = 83% to 94%; τ2 = 0.0070; I2 = 62%; overall p

Date: 2024
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0307981

DOI: 10.1371/journal.pone.0307981

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