Three months use of Hybrid Closed Loop Systems improves glycated hemoglobin levels in adolescents and children with type 1 diabetes: A meta-analysis

Yuan-yuan Wang, Hui-min Ying, Fang Tian, Xiao-lu Qian and Zhen-feng Zhou

PLOS ONE, 2024, vol. 19, issue 8, 1-14

Abstract: Background: Longer outpatient studies have demonstrated that hybrid closed loop (HCL) use has led to a concomitant reduction in glycated hemoglobin(HbA1c) by 0.3%–0.7%. However, reports have also indicated that HbA1c levels are not declined in the long-term use of HCL. Therefore, we wonder that 3 months use of HCL could improve glycated hemoglobin levels in adolescents and children with T1D. Methods: Relevant studies were searched electronically in the Cochrane Library, PubMed, and Embase utilizing the key words “Pediatrics or Child or Adolescent”, “Insulin Infusion Systems” and “Diabetes Mellitus” from inception to 17th March 2024 to evaluate the performance of HCL on HbA1c in adolescents, and children with T1D. Results: Nine studies involving 927 patients were identified. Three months use of HCL show a beneficial effect on HbA1c management (p 0.05). The overall percentage of hyperglycemic time was significantly decreased in HCL group compared to the control group when it was defined as >180 mg/dL (p 250 mg/dL (p = 0.007, I2 = 86%) and >300 mg/dL (p = 0.005; I2 = 76%). The mean glucose level was significantly decreased by HCL (p

Date: 2024
References: Add references at CitEc
Citations:

Downloads: (external link)
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0308202 (text/html)
https://journals.plos.org/plosone/article/file?id= ... 08202&type=printable (application/pdf)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0308202

DOI: 10.1371/journal.pone.0308202

Access Statistics for this article

More articles in PLOS ONE from Public Library of Science
Bibliographic data for series maintained by plosone ().