Effects of moderate doses of ionizing radiation on experimental abdominal aortic aneurysm

Goran Riazi, Chloe Brizais, Imene Garali, Rida Al-rifai, Helene Quelquejay, Virginie Monceau, Guillaume Vares, Lea Ould-Boukhitine, Damien Aubeleau, Florian Gilain, Celine Gloaguen, Morgane Dos Santos, Hafid Ait-Oufella and Teni Ebrahimian

PLOS ONE, 2024, vol. 19, issue 8, 1-19

Abstract: Background: Exposure to ionizing radiation has been linked to cardiovascular diseases. However, the impact of moderate doses of radiation on abdominal aortic aneurysm (AAA) remains unknown. Methods: Angiotensin II-infused Apoe-/- mice were irradiated (acute, 1 Gray) either 3 days before (Day-3) or 1 day after (Day+1) pomp implantation. Isolated primary aortic vascular smooth muscle cells (VSMCs) were irradiated (acute 1 Gray) for mechanistic studies and functional testing in vitro. Results: Day-3 and Day+1 irradiation resulted in a significant reduction in aorta dilation (Control: 1.39+/-0.12; Day-3: 1.12+/-0.11; Day+1: 1.15+/-0.08 mm, P

Date: 2024
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0308273

DOI: 10.1371/journal.pone.0308273

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