A causal relationship between sarcopenia and cognitive impairment: A Mendelian randomization study

Hengzhi Liu, Yi Fan, Jie Liang, Aixin Hu, Wutong Chen, Hua Wang, Yifeng Fan, Mingwu Li, Jun Duan and Qinzhi Wang

PLOS ONE, 2024, vol. 19, issue 9, 1-11

Abstract: Objective: Sarcopenia and cognitive impairment often coexist in the elderly. In this study, we investigated the causal relationship between sarcopenia-related muscle characteristics and cognitive performance. Methods: We used linkage disequilibrium score regression (LDSC) and Mendelian Randomization (MR) analyses to estimate genetic correlations and causal relationships between genetically predicted sarcopenia-related muscle traits and cognitive function, as well as cognitive function-based discovery samples and replicated samples. Estimated effect sizes were derived from a fixed-effects meta-analysis. Results: Our univariate genome-wide association study (GWAS) meta-analysis indicated a causal relationship between appendicular lean mass (ALM) (β = 0.049; 95% confidence interval (CI): 0.032–0.066, P

Date: 2024
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0309124

DOI: 10.1371/journal.pone.0309124

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