Prescription trends in Japanese advanced Parkinson’s disease patients with non-motor symptoms: J-FIRST

Masahiro Nomoto, Yoshio Tsuboi, Kenichi Kashihara, Shih-Wei Chiu, Tetsuya Maeda, Hidemoto Saiki, Hirohisa Watanabe, Yasushi Shimo, Nobutaka Hattori, Takuhiro Yamaguchi and on behalf of the J-FIRST Investigators

PLOS ONE, 2024, vol. 19, issue 10, 1-15

Abstract: Background: Non-motor symptoms (NMS) are important factors when selecting treatments for patients with advanced Parkinson’s disease (PD). We sought to elucidate the prescribing practices for advanced PD patients with NMS in Japanese clinical practice. Methods: We examined the prescription rates and doses of anti-PD drugs, and the use of non-steroidal anti-inflammatory drugs (NSAIDs) in post hoc analyses of a 52-week observational study of 996 PD patients with wearing-off on levodopa-containing therapy and ≥1 NMS. Results: Dopamine agonists were the most frequently prescribed drugs combined with levodopa-containing drugs, followed by entacapone, zonisamide, istradefylline, selegiline, and amantadine. The daily dose of levodopa-containing drugs, rotigotine, entacapone, istradefylline, and droxidopa, and the levodopa-equivalent dose increased during the observation period. In a subgroup analysis of patients stratified by NMS status (improved/unchanged/deteriorated), the deteriorated group had higher prescription rates of entacapone and istradefylline, whereas the improved group had higher prescription rates of NSAIDs and zonisamide at Week 52. Prescriptions varied by geographical region for anti-PD drugs and by NMS status for NSAIDs. Conclusions: There were significant changes in the prescriptions and dosing of selected anti-PD drugs, especially newer drugs. Anti-PD drug and NSAID prescriptions also varied by changes in NMS status and geographic region.

Date: 2024
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0309297

DOI: 10.1371/journal.pone.0309297

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