Myosteatosis and the clinical outcomes of patients with liver cirrhosis: A meta-analysis

Haojie Xue, Yihan Liu, Yang Liu, Han Li, Qian Liang, Longhui Ma, Junying Liu and Ming Zhao

PLOS ONE, 2024, vol. 19, issue 9, 1-19

Abstract: Objectives: This study aimed to examine the potential correlation between myosteatosis and the prognosis of patients diagnosed with liver cirrhosis by a meta-analysis. Methods: Cohort studies of relevance were acquired through comprehensive searches of the Medline, Web of Science, and Embase databases. To account for heterogeneity, a random-effects model was employed to combine the findings. Results: The meta-analysis included 10 retrospective and four prospective cohort studies, encompassing a total of 4287 patients diagnosed with cirrhosis. The pooled findings indicated a notable decline in transplant-free survival (TFS) among individuals with liver cirrhosis and myosteatosis compared to those without this condition (risk ratio: 1.94; 95% confidence interval: 1.61 to 2.34, p 0.05 for all subgroup differences). Additionally, Egger’s regression test indicated the presence of significant publication bias (p = 0.044). However, trim-and-fill analysis by including three hypothesized studies showed consistent results. Conclusions: The presence of myosteatosis in individuals diagnosed with liver cirrhosis may potentially be linked to a poor TFS prognosis. Further investigations are required to ascertain whether enhancing myosteatosis could potentially yield a survival advantage for this particular patient population.

Date: 2024
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0310017

DOI: 10.1371/journal.pone.0310017

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