Real-world visual acuity outcomes for patients with naïve neovascular age-related macular degeneration treated with aflibercept, ranibizumab, or bevacizumab in the Republic of Korea

Yeo Jin Lee, Seungbum Kang, Jae Yon Won, Young Jung Roh, Ho Ra, Mee yon Lee, Sung Pyo Park and Dong Hyun Jee

PLOS ONE, 2024, vol. 19, issue 10, 1-13

Abstract: Background: To compare the visual outcomes of different anti-vascular endothelial growth factor (VEGF) drugs, including aflibercept, ranibizumab, and bevacizumab, in a real-world setting in Korea. Methods: We collected data from patients who received monotherapy using one of these three anti-VEGF drugs as naïve treatment after being diagnosed with neovascular age-related macular degeneration. The number of injections and visual acuity (VA) outcomes of each cohort were obtained and pairwise comparisons were performed using propensity score matching. Results: A total of 254 aflibercept, 238 ranibizumab, and 282 bevacizumab treatment-naïve eyes were included. The mean VA change at 3 years for all cohorts combined was -1.8 letters, and the mean number of injections was 9.4. In the direct comparison of the three drugs, the mean change in the VA letter score was +2.0 letters for aflibercept and -11.7 letters for bevacizumab (P

Date: 2024
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0310381

DOI: 10.1371/journal.pone.0310381

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