Analysis of rare coding variants in 470,000 exome-sequenced subjects characterises contributions to risk of type 2 diabetes

David Curtis

PLOS ONE, 2024, vol. 19, issue 12, 1-12

Abstract: Aims: To follow up results from an earlier study using an extended sample of 470,000 exome-sequenced subjects to identify genes associated with type 2 diabetes (T2D) and to characterise the distribution of rare variants in these genes. Materials and methods: Exome sequence data for 470,000 UK Biobank participants was analysed using a combined phenotype for T2D obtained from diagnostic and prescription data. Gene-wise weighted burden analysis of rare coding variants in the new cohort of 270,000 samples was carried out for the 32 genes previously significant with uncorrected p

Date: 2024
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0311827

DOI: 10.1371/journal.pone.0311827

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